PI/PC-PLC-Independent Effects of Exendin-4 While GLP-1 has been shown to regulate the phosphatidylinositol-phospholipase C (PI-PLC) or phosphatidylcholine-phospholipase C (PC-PLC) activity in mouse pancreatic cells [56], experiments with the PI-PLC inhibitor U73122 or with the PC-PLC inhibitor D609, did not support the involvement of these two pathways in the exendin-4 effects on GCs
(Innopeptides)
However, using both medications togetheror combining them with similar drugsis not recommended
People taking GLP-1 medications commonly report reduced food cravings, less emotional eating, and a quieting of the constant mental preoccupation with food that researchers call "food noise." Animal studies have also shown that GLP-1 receptor activation reduces the rewarding properties of high-calorie food in the brain findings confirmed in a landmark randomized, placebo-controlled neuroimaging study in humans ( van Bloemendaal et al., Diabetes, 2014 )
In published medical and biochemical literature, GHK-Cu is associated with signaling that supports extracellular matrix maintenance, including collagen and elastin-related pathways
